mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation
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mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation
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mTOR (mechanistic Target Of Rapamycin) senses nutrients and decides whether your cells should grow or repair. High nutrients → mTOR up → Growth mode Low nutrients → mTOR down → Maintenance mode Here's why it matters: The maintenance state (low mTOR) is associated with slower aging. Animals with reduced mTOR activity tend to live longer and remain healthier. What affects mTOR: Fasting/caloric restriction (lowers it) Protein intake (raises it) Exercise (raises it acutely) Rapamycin (inhibits it) Y
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