Harcombe et al have conducted a systematic review and meta-analysis of randomised controlled trials (RCTs) that would have been available to the regulatory committees in the USA and the UK when ...

‘I know of no single acceptable study that shows a high intake of sugar in a population that is almost entirely free from heart disease.’1—John Yudkin The evidence incriminating insulin and ...

Objective We aimed to compare the early haemodynamic data of the On-X and St Jude Medical (SJM) Regent bileaflet mechanical prostheses in the aortic position.Methods A retrospective study was ...

Conclusion This study highlights significant treatment disparities in AVR among octogenarians with high-gradient sAS despite clear benefits in survival and reduced hospitalisations. The findings ...

Supplemental glycine, via activation of glycine-gated chloride channels that are expressed on a number of types of cells, including Kupffer cells, macrophages, lymphocytes, platelets, cardiomyocytes ...

Introduction Recent studies have highlighted the presence of right ventricular dysfunction (RVD) in a substantial proportion of peripartum cardiomyopathy (PPCM), with evidence suggesting that RVD is ...

Objective Reduced exercise capacity is well documented in end-stage chronic kidney disease (CKD), preceded by changes in cardiac morphology in CKD stage 3. However, it is unknown whether subclinical ...

Background There has been rapid growth in the demand for transcatheter aortic valve replacement (TAVR), which has the potential to overwhelm current capacity. This imbalance between demand and ...

Background The prognosis of myocardial ischaemia with no obstructive coronary artery disease (INOCA) and its underlying vasomotor disorders, vasospastic angina (VSA) and microvascular angina (MVA), is ...

Background Cardiovascular-kidney-metabolic (CKM) syndrome plays a critical role in the pathogenesis of cardiovascular diseases (CVD). Growing evidence has established that impaired intrinsic capacity ...

Background Heart failure with preserved ejection fraction (HFpEF) poses global diagnostic and therapeutic challenges, with potential regional differences in clinical practice that remain underexplored ...

Background Cardiac amyloidosis (CA) is the leading cause of mortality in systemic amyloidosis, highlighting the need for accurate risk assessment to guide patient management. While the diagnostic ...