Historically, the vast majority of pharmaceutical drugs have been meticulously designed down to the atomic level.

The development and spread of antibiotic resistance represents one of the greatest threats to global health. To overcome ...

Could a gene regulatory network in gut microbes have evolved its elaborate and tightly regulated molecular machinery only to pump out antibiotics indiscriminately? Researchers show this is an ...

have tackled this problem head-on by designing a class of MOFs that incorporate structures called pillar[5]arene rings into a MOF framework (Fig. 1). Pillar[5]arenes are molecular rings that bind ...

Led by Professor Sigal Ben-Yehuda and Professor Ilan Rosenshine from the Department of Microbiology and Molecular Genetics, the research uncovers a direct connection between the rotation of bacterial ...

I was particularly interested in the fact that its most studied function, antibiotic resistance ... as they recognize a widespread molecular structure found in many organic molecules.

coli, including EPEC which is a major cause of diarrheal disease, are becoming increasingly resistant to the antibiotics ... EspC as a molecular weapon. "It was already known that EPEC used EspC as a ...

Paenibacillus was found to produce a new substance that attacks antibiotic ... has a unique structure of a "knotted lasso or a pretzel." "Lariocidin binds to the molecular machine, the ribosome ...

In seeking new antibiotic sources ... guided design" in which they made tiny changes to the peptide's chemical structure until they found a form that resisted clumping and could hold therapeutic ...