clinicaltrialsarena

Roche’s Phase III trial of fenebrutinib in RMS meets primary endpoint

The FENhance 1 and 2 trials involved 1,497 adults with RMS. Credit: New Africa / Shutterstock.com. Roche has reported that the pivotal Phase III FENhance 1 trial of its investigational Bruton’s ...
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FDA releases hold on second of Intellia’s ATTR-CM gene therapy trials

The US Food and Drug Administration (FDA) has released the clinical hold on a second trial evaluating Intellia Therapeutics’ transthyretin amyloidosis with cardiomyopathy (ATTR-CM) gene therapy. The ...
Clinical Trials Arena

BlueWind’s Revi urinary incontinence device demonstrates three-year efficacy

Medtech companies like BlueWind or Medtronic are increasingly investing in neuromodulation to treat urgency urinary ...
Clinical Trials Arena

MSD announces results from Keytruda combination trial for RCC

MSD has announced findings from the pivotal Phase III LITESPARK-022 trial, assessing the Keytruda-Welireg combination as adjuvant therapy for patients with clear cell RCC after nephrectomy.
Clinical Trials Arena

Opus Genetics reports Phase I/II trial results of OPGx-BEST1 gene therapy

Opus Genetics has reported early findings from its ongoing Phase I/II clinical trial of the OPGx-BEST1 gene therapy to treat ...
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FDA tells uniQure to conduct another study of Huntington’s gene therapy

uniQure will run another trial of its Huntington’s Disease gene therapy following the FDA’s review. Credit: Vink Fan / Shutterstock.com uniQure’s stock has dropped by more than 40% after being asked ...
Clinical Trials Arena

OCT West Coast: China’s clinical trial infrastructure delivers upto 60% cost savings

Faster and more cost-effective trials support early-stage research in China driving the country's drug discovery engine.
Clinical Trials Arena

Lilly reports ACHIEVE-3 trial outcomes for type 2 diabetes

Eli Lilly and Company has reported detailed findings from the ACHIEVE-3 Phase III trial comparing the efficacy and safety of orforglipron and oral semaglutide in adults with type 2 diabetes ...
Clinical Trials Arena

Podcast: Rare Disease Day: FDA guidance allowing advancement

Ahead of Rare Disease Day, Abigail Beaney, editor of Clinical Trials Arena, spoke with Robert Barrie, editor of Pharmaceutical Technology and Frankie Fattorini, reporter for Pharmaceutical Technology ...
Clinical Trials Arena

Synthekine and MSD collaborate for STK-012 combination trial to treat NSCLC

Synthekine has entered into a clinical trial partnership and supply agreement with MSD to investigate STK-012 in combination with Keytruda and chemotherapy in patients with first-line, PD-L1 negative ...
Clinical Trials Arena

Mahzi doses first patient in MZ-1866 trial for Pitt Hopkins syndrome

Mahzi Therapeutics has dosed the first patient in its Phase I/II UNITE study assessing MZ-1866, an investigational gene ...
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AtaiBeckley’s MDMA-based drug for anxiety shows benefit in Phase IIa trial

The double-blind, placebo controlled trial enrolled 71 patients with SAD. Credit: Elena Kalinicheva / Shutterstock.com AtaiBeckley’s social anxiety disorder (SAD) drug has shown both safety and early ...