BMJ

Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation

1 Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK 2 Department of Rheumatology, Medical School, Newcastle University, Newcastle upon Tyne, UK 3 Department ...
BMJ

Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care

Dr G Peat, Primary Care Sciences Research Centre, School of Postgraduate Medicine, Keele University, The Medical Institute, Hartshill Road, Stoke-on-Trent ST7 4NY, UKg.m.peat{at}hfac.keele.ac.uk ...
BMJ

Radiographic scoring methods as outcome measures in rheumatoid arthritis: properties and advantages

UPRES EA 1124- Ecole de Santé Publique, Faculté de Médecine, Nancy, France Professor F Guillemin, Ecole de Santé Publique, Faculté de Médecine, 9 Avenue de la Forêt de Haye, BP 184, F 54500 Vandoeuvre ...
BMJ

Validation of a prediction rule for development of rheumatoid arthritis in patients with early undifferentiated arthritis

Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada Correspondence to Dr B Kuriya, University of Toronto, Wolf and Lebovic Building, 60 Murray Street, Box ...
BMJ

Dose-related patterns of glucocorticoid-induced side effects

Objective: To identify patterns of self-reported health problems relating to dose and duration of glucocorticoid intake in unselected patients with rheumatoid arthritis from routine practice. Methods: ...
BMJ

Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes

Objectives Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low ...