Researchers at the National Institutes of Health (NIH) have discovered clues as to how our bodies turn sensations such as heat and touch into signals sent to the brain—and how these signals can be ...

Researchers uncover the cellular and molecular basis for sensing heat and inflammatory pain.

This valuable study combines real-time keypoint tracking with transdermal activation of sensory neurons to investigate sensory neuron recruitment in freely moving mice, and builds on the authors' ...

In the nociceptive lineage, we demonstrate that this concomitant temporal extinction of Dach1 involves the nociceptor-specific transcriptional regulator Prdm12. Genetic depletion of Dach1 during its ...

During the transduction phase, noxious, thermal, mechanical or chemical stimuli are trigger the release of nociceptor-sensitizing substances such as bradykinin, serotonin, histamine, prostaglandins, ...

The research team used the nociceptor-based microfluidic biosensor, aka pain-on-a-chip, to differentiate between blood samples extracted from two different animal models of chronic pain – one focusing ...