The past few decades have seen growing interest in the neuropsychiatric syndrome of apathy, conceptualised as a loss of motivation manifesting as a reduction of goal-directed behaviour. Apathy occurs ...

3 Working Group ‘Deep Brain Stimulation in Psychiatry: Guidance for Responsible Research and Application’. This Working Group is organised by the Europäische ...

Objective Deep brain stimulation (DBS) reduces depressive symptoms in approximately 40%–60% of patients with treatment-resistant depression (TRD), but data on long-term efficacy and safety are scarce.

Background To delineate the clinical characteristics and outcomes of late-onset myelin oligodendrocyte glycoprotein antibody-associated disease (LO-MOGAD) and compare them with those of early-onset ...

Dr JL Iddon, Department of Academic Neurosurgery, Box 167, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 5RG, UK email jo.iddon{at}cenes.co.uk OBJECTIVES Eleven patients ...

Objective Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult ...

Objective While isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or ...

Correspondence to: Dr E H Reynolds, Institute of Epileptology, Weston Education Centre, King's College Denmark Hill Campus, Cutcombe Road, London SE5 9PJ, UK During three decades of neurological ...

Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a ...

Psychogenic non-epileptic seizures (PNES) represent a diagnostic challenge. When trying to distinguish between PNES and epileptic seizures (ES), clinicians rely on the presence or absence of several ...

A systematic review and meta-analysis were conducted to quantify the efficacy of transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT) for the treatment of motor dysfunction in ...

1 Department of Neurology, Medical Centre Haaglanden, The Hague, The Netherlands 2 Department of Neurology, Maasstad Hospital, Rotterdam, The Netherlands 3 Department of Radiology, Medical Centre ...