Anti-inflammatory drugs have long served as a cornerstone in the treatment of conditions marked by inflammation, pain, and fever. At the heart of many of these therapeutic agents lies the inhibition ...

BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...

The painkilling, antipyretic, and antiinflammatory properties of aspirin have been known for centuries. The understanding that aspirin targets cyclooxygenase-1 (COX-1) (also known as ...

This project is not being offered for the current term. Please check back next semester for updates. The cyclooxygenase enzymes (COX-1 and COX-2) catalyze the committed step in the biosynthesis of ...

Study shows that NSAIDs disrupt epithelial cells in the colon and sensitize them to C. difficile toxins by perturbing cell mitochondria Prior studies have shown that NSAIDs like indomethacin, aspirin, ...

Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paper ...

B O S T O N, Sept. 12 -- Here’s news arthritis sufferers should be able to stomach. New research on two recently released blockbuster arthritis pain medications confirms earlier claims the drugs cause ...

Reston, VA (March 28, 2025)—A novel PET imaging approach can effectively quantify a key enzyme associated with brain inflammation, according to research published in the March issue of The Journal of ...