Randomization was generated by a 24-hour, real-time central network system and was based on the simple randomization method without stratification.

The randomization sequence was prepared by an independent data coordinating center and followed the simple randomization method with stratification according to clinical site.

In many settings in which Monte Carlo methods are applied, there may be no known algorithm for exactly generating the random object for which an expectation is to be computed. Frequently, however, one ...