A 3D model of the nucleus made with SPRITE: DNA regions in the "inactive hub" on chromosomes 15 (orange) and chromosome 18 (green) coming together around a large nuclear body in the nucleus (blue ...

For the first time, researchers have mapped the cell nucleus in 3D, revealing the packaging and organization of a cell's DNA in unprecedented detail.

The study on NPCs in C2C12 cells imaged with a SSMI derivative was published by UCSF researchers. This SSMI derivative is known as 3D structured illumination microscopy or 3D-SIM.