Technical Terms Progressive Alignment: An approach that constructs multiple sequence alignments by iteratively aligning pairs of sequences, typically guided by a phylogenetic tree.

Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 69, No. 2 (2020), pp. 301-325 (25 pages) The structure of a protein is crucial in determining its functionality and is ...

Edgar calls his new algorithm MUSCLE (multiple sequence comparison by log expectation). MUSCLE uses a log expectation score to control progressive alignment of the input amino acid sequences. This ...

Important new studies of the evolution of birds and mammals relied on Progressive Cactus, a genome alignment tool developed at the UC Santa Cruz Genomics Institute.

Multiple sequence alignment (MSA) is a cornerstone of computational biology, facilitating the exploration of functional, structural and evolutionary relationships among biological sequences.

Three new articles present major advances in understanding the evolution of birds and mammals, made possible by new methods for comparing the genomes of hundreds of species. Researchers developed a ...