Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function.

The Mannan-binding lectin serine protease (MASP) protein family is critical for the complement pathway in the immune system.

The classical pathway is activated by antibody–antigen complexes, whereas the other two pathways — the lectin and alternative pathways — function in innate immune defence.

The lectin pathway of complement activation is an important component of the innate immune defense. The initiation complexes of the lectin pathway consist of a recognition molecule and associated ...

Its pathogenesis is complex and not well understood, but there is increasing evidence that the lectin-driven complement activation may be behind it. Mannose-binding lectin serine protease 2 (MASP-2) ...

Three pathways have now been described in the complement system — the classic, alternative and lectin. A fourth, lytic pathway is added by some authors for membrane attack complex.

Deficiencies in the innate immunity lectin pathway of complement activation are implicated in a child’s vulnerability to infections in conditions such as cancer, but the role during critical ...

The panel discussed the emerging evidence that endothelial injury and the activation of the lectin pathway of complement are central drivers of the acute respiratory distress syndrome (ARDS) and ...