The finding — from high-pressure research that squeezed curium-containing compounds between diamonds — could guide further studies on curium and other mysterious heavy elements.

Researchers found that an increased inactivation efficiency rate was linked to greater drug potency, but only to a certain point. Eventually, as the TCIs worked faster, their potency plateaued and the ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

In addition to bond-selected dissociation, we further investigated the Au–S interaction by manipulating single gold atoms to form covalent and coordinate bonds between the Au atoms and the S ...

Unlike drugs that form reversible, noncovalent interactions, covalent compounds permanently shut down the disease-linked proteins they bind to, resulting in a potent therapy with a long action time.

Experimental evidence has confirmed earlier computational studies showing that the Au–C bonds in Au(CN) 2-have significant covalent character, in contrast to the ionic behavior of gold's lighter ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with ...