Researchers found that an increased inactivation efficiency rate was linked to greater drug potency, but only to a certain point. Eventually, as the TCIs worked faster, their potency plateaued and the ...

Unlike drugs that form reversible, noncovalent interactions, covalent compounds permanently shut down the disease-linked proteins they bind to, resulting in a potent therapy with a long action time.

In fact, from 2013-2021, eight drugs utilizing targeted covalent inhibitors (TCI) to treat lymphoma, lung cancer, and breast cancer have been approved. Today, scientists have designed “warheads” with ...

Experimental evidence has confirmed earlier computational studies showing that the Au–C bonds in Au(CN) 2-have significant covalent character, in contrast to the ionic behavior of gold's lighter ...

The finding — from high-pressure research that squeezed curium-containing compounds between diamonds — could guide further studies on curium and other mysterious heavy elements.

In addition to bond-selected dissociation, we further investigated the Au–S interaction by manipulating single gold atoms to form covalent and coordinate bonds between the Au atoms and the S ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with ...