The team succeeded in simulating the time course of transitions in the 3D structure of the GPCRs during the process of signal transduction across the cell membrane.

Collaborative Research Centre (CRC) 1423, “Structural Dynamics of GPCR Activation and Signal Transduction”, led by biochemists Professor Annette Beck-Sickinger and Professor Torsten ...

G protein-coupled receptors (GPCRs) are essential for cell signal transduction and comprise the largest drug target protein family. Upon agonist stimulation, these receptors activate multiple ...

Researchers have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery opens the ...

Moreover, as negative regulators of GPCR signal transduction, the RGS proteins are intriguing potential drug targets, since their inhibition should lead to prolonged signaling from G proteins ...

G-protein coupled receptors (GPCRs) are plasma membrane-spanning proteins which transduce specific physical and chemical extracellular signals into the cell. In contrast to animal cells, signal ...

"Moreover, mitochondria have another capacity that qualifies them as organelles for signal transduction: they are mobile and can dock onto motor proteins in the cell." ...

Given their role in modulating GPCR signal transduction (Figure 1), it is not surprising that RGS proteins have been implicated as potential drug targets for diverse therapeutic areas, including ...