Microsoft Excel comes with a lot of built-in functionality that doesn't restrict you to comparing data in two columns using only one method.

How to compare columns in Microsoft Excel As stated, we can use the Excel VLOOKUP function to find and match different data or find differences in two columns.

Matching One Column Data with Another in Excel. If you don't have a keen eye and a perfect memory, you probably can't spot all the differences between two data columns in a large worksheet.

Calculate the difference between two values in your Microsoft Excel worksheet. Excel provides one general formula that finds the difference between numbers, dates and times.