How to compare columns in Microsoft Excel As stated, we can use the Excel VLOOKUP function to find and match different data or find differences in two columns.

Matching One Column Data with Another in Excel. If you don't have a keen eye and a perfect memory, you probably can't spot all the differences between two data columns in a large worksheet.

Microsoft's Excel software is one of the best tools for you to organize, analyze, and manipulate data. Here are three ways to compare data in two columns.