Power analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required sample size for ...

Larger sample sizes not only increase the power of achieving trial objectives but also increase trial cost and duration. Despite flourishing literature in novel dose-finding designs, only a limited ...

In epidemiologic studies and disease prevention trials, interest often involves estimation of the relationship between some disease endpoints and individual exposure. In some studies, due to the ...

Course TopicsPower analyses and sample size calculations are important parts of many research projects. Often, before data are even collected, it is necessary to calculate and justify the required ...

Over-dispersed count data are frequently observed in clinical trials where the primary endpoint is occurrence of clinical events. Sample sizes of comparative clinical trials with these data are ...