What each prominent club in the 2024/25 Champions League table must do to see themselves through to the knockout stage of the competition.

Abstract Reversing the loop lengths of the small protein S6 by circular permutation has a dramatic effect on the transition state structure: it changes from globally diffuse to locally condensed.

Circular permutation of a protein consists of connecting the native N- and C-termini covalently with a peptide linker and cleaving the peptide backbone at one specific site 3.