San Francisco 49ers star George Kittle gives Philadelphia Eagles fans a shoutout before the Wild Card playoff game.

The Philadelphia Eagles are ready to unleash the full force of dual threat quarterback Jalen Hurts as they open their NFL postseason campaign on Sunday with a wild card clash against a depleted San Francisco 49ers line-up.

All margins matter as the Eagles begin their fifth straight playoff appearance. Their advantage in the red zone will be tested in Sunday’s NFC wild-card game against the San Francisco 49ers, whose middling defense becomes one of the NFL’s best when backed up in their own territory.

“ (49ers head coach) (Kyle) Shanahan has publicly said it and (Rams head coach) (Sean) McVay tells me often, they lay awake at night thinking of Vic Fangio," ESPN’s Peter Schrager said this week on First Take. “That man is a genius."

PHILADELPHIA - Perhaps the most interesting matchup during Sunday’s Wild Card Weekend matchup between the San Francisco 49ers and the Philadelphia Eagles isn’t

The Philadelphia Eagles are slight betting favorites against the San Francisco 49ers in the NFC Wild Card round.