As people age, muscles naturally lose mass and strength, a condition known as sarcopenia. The decline can make everyday activities harder and increases the risk of falls, disability and early death.

This genetic model suggests otherwise, indicating that coupled gating or other mechanical interactions, rather than CICR, drive activation of uncoupled RyR1 channels. Interestingly, the researchers ...

Researchers have identified the role of the large Maf transcription factor family in regulating fast twitch muscle fibers. A mouse model lacking Maf expression in the skeletal muscles exhibited a ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Supplementing a single protein found in the spinal cord could help prevent symptoms of Lou Gehrig's disease, according to a new study. Researchers found high levels of the protein -- called mitofusion ...

If your fitness goal is to up the ante on endurance, pack more power into your sprint, or supercharge your strength gains in the gym, it’s worth exploring – what are the different muscle fiber types?

Most fitness-minded people have probably heard of fast- and slow-twitch muscle fibers. However, the distinction can be somewhat mysterious, especially in the context of understanding how it relates to ...