Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells ...

"The germinal center is using a really smart strategy to do two things at once—two things that are, at face value, ...

Patients with a immunohistochemically defined, germinal-center tumor subtype have an improved outcome compared with patients with the non-germinal-center phenotype when treated with CHOP only ...

Vaccines and infections alike lead to the construction of germinal centers, specialized immune structures where B cells ...

Germinal centers rapidly introduce mutations into an otherwise average army of B cells. But since mutagenesis is random, the probability of B cells acquiring worthless or deleterious mutations far ...

New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

Get Instant Summarized Text (Gist) Germinal centers in lymph nodes refine antibodies by balancing rapid B cell proliferation with mutation suppression. Advanced imaging techniques reveal that ...