Die Ewigkeitschemikalie PFOS kann einen zentralen Schalter der angeborenen Virusabwehr blockieren. Experimente zeigen, dass der Stoff direkt an den ...
Оказалось, что молекулы PFOS способны соединяться с белком IRF3 — одним из ключевых компонентов врожденной иммунной системы, ...
Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding ...
Activation of the transcription factor IRF3, a central regulator of type I interferon signaling, is induced through the phosphorylation of serine and threonine residues in the transactivation domain ...
本研究针对狼疮性肾炎（LN）中足细胞损伤的分子机制展开探索，发现E3连接酶HERC5通过促进IRF3的ISGylation抑制其泛素化降解，稳定IRF3蛋白并增强其活性，进而驱动IFN-β的持续产生和过度活化 ...
Mechanistically, the researchers found that SET7 interacts with IRF3 and catalyzes its monomethylation at lysine 98. This methylation decreases IRF3 phosphorylation, dimerization, and subsequent ...
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and is characterized by an abnormal inflammatory reaction of the lungs to inhaled particles, such as ...
Demnach unterdrücken bereits subtoxische PFOS-Dosen die angeborene antivirale Immunantwort, indem die Substanz an den Interferon-Regulationsfaktor 3 (IRF3) bindet, die Typ-I-Interferon-Produktion ...
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