Germinal center (GC) B cells are responsible for producing antibodies. The cells have some of the highest proliferation rates of all mammalian cells, yet their metabolism is unusual and ...

This built-in safeguard allows germinal centers to mass-produce successful clones without compromising antibody quality. The ...

B cells in lymphoid organs undergo germinal center reactions. The image on the left is an immunized mouse spleen with activated B cells (brown) that produce antibodies. At right, top: a scanning ...

Activated B cells give rise germinal centers (shown in red), where mature B cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse ...