Objective: The Diabetes Prevention Program (DPP) demonstrated that intensive lifestyle and metformin interventions reduced the incidence of type 2 diabetes compared with a placebo intervention.

Three decades of landmark research into type 2 diabetes prevention abruptly ended this month due to government funding cuts.

DPP-4s are typically safe and don’t cause hypoglycemia when taken alone or with metformin ... There are a number of ongoing clinical trials for type 2 diabetes research. The National Institutes ...

In our view, the translation of preventive strategies from clinical trials to clinical practice ... For example, the average weight loss in the DPP 3 was associated with a 58% average reduction ...

DPP investigators were told to immediately stop ... of 7% weight loss reduced the incidence of type 2 diabetes by 58% and metformin reduced it by 31%. To prevent one case of diabetes within ...

Treatment with metformin was associated with a reduction ... This analysis also evaluated other antidiabetic medications, including DPP-4 inhibitors, sulfonylureas, SGLT2 inhibitors, and insulin ...

(HealthDay News) — For older adults with type 2 diabetes (T2D), use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with a modestly lower risk for depression compared with ...

During a 72-week trial, participants saw a “substantial ... the ACP also recommends against the use of DPP-4 inhibitors alongside metformin, because new evidence showed DPP-4s didn’t reduce ...

Sitagliptin, metformin (as HCl) ext-rel ... History of angioedema to other DPP-4 inhibitors. Elderly, debilitated, uncompensated strenuous exercise, malnourished or deficient caloric intake ...

Over the first 3 years of the DPP, there were three ... cost $15,700 and the metformin intervention cost $31,300 per case of diabetes prevented during the trial ( Table 3). From the perspective ...