New research combines two powerful imaging techniques to study the complete structure of a common aGPCR, including how its long and complex extracellular region interacts with the transmembrane region ...
Cell surface receptors, such as the G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK), play central roles signalling pathways. Due to their central role in regulating a wide range ...
Recently these monocyte-derived alveolar macrophages, or Mo-AMs, were identified as key drivers of lung fibrosis disease progression. However, the mechanisms of their pro-fibrotic behavior and ...
This new technique for studying cell receptors could have sweeping implications for drug development
Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...
Veronica Paulus is a former STAT intern supported by the Harvard University Institute of Politics. One in five individuals who receive a kidney transplant experience a rejection episode within a year.
Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...
BIRMINGHAM, Ala. – Lung macrophages play a pivotal role in diseases like idiopathic pulmonary fibrosis. Two types of macrophages — the white blood cells that defend the body by killing microbes, ...
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