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How a crucial DNA repair protein works—and what it means for cancer treatment
The findings, published in Nature Structural & Molecular Biology, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By unveiling Pol-theta's ...
Scientists Capture First-Ever Images of Cancer’s Covert DNA Repair Strategy
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
Nature3y
DNA Is Constantly Changing through the Process of Recombination
Beyond its role in meiosis, recombination is important to somatic cells in eukaryotes because it can be used to help repair broken DNA, even when the break involves both strands of the double helix.
mskcc.org6y
DNA Damage Recognition and Repair by DNA Ligases
ChVLig encircles the DNA as a C-shaped protein clamp. The NTase domain binds to the broken and intact DNA strands in the major groove flanking the nick and also in the minor groove on the 3’-OH side ...
technologynetworks15d
Mechanism of Key DNA Repair Protein Advances Cancer Treatment
The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands. By ...
EurekAlert!14d
How a crucial DNA repair protein works—and what it means for cancer treatment (IMAGE)
The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer.
EurekAlert!16d
How a crucial DNA repair protein works—and what it means for cancer treatment
The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors ...
Science Daily16d
How a crucial DNA repair protein works -- and what it means for cancer treatment
The findings, published in Nature Structural & Molecular Biology on February 28, 2025, illuminate how Pol-theta undergoes a major structural rearrangement when it binds to broken DNA strands.