Pro Bowl left tackle Trent Williams and receiver Ricky Pearsall both missed practice Wednesday for the San Francisco 49ers, putting their status for the wild-card playoff game against the Philadelphia Eagles in question.

Whoever wins Saturday's game in San Francisco will be the NFC's No. 1 seed and NFC West champion. It's a crucial game for division bragging rights and also both teams' title hopes, as the No. 1 seed would secure home-field advantage throughout the playoffs.