Otis Air National Guard Base is an Air National Guard installation located within Joint Base Cape Cod, a military training facility located on the western portion of Cape Cod in Barnstable County, Massachusetts, United States. It was known as Otis Air Force Base prior to its transfer from the active duty Air Force to the Air National Guard. In the local communit…Otis Air National Guard Base is an Air National Guard installation located within Joint Base Cape Cod, a military training facility located on the western portion of Cape Cod in Barnstable County, Massachusetts, United States. It was known as Otis Air Force Base prior to its transfer from the active duty Air Force to the Air National Guard. In the local community, it is more commonly known as Otis Air Base or simply Otis. It was named in honor of pilot and Boston surgeon Lt. Frank "Jesse" Otis.